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The most commonly reported side effects in Phase 2 trials were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which were generally mild to moderate and tended to improve over time

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Semaglutide works by mimicking the action of GLP-1, a hormone that increases insulin release, decreases sugar production by the liver, and decreases appetite

The recent conclusion of major phase 3 trials for the oral glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide represents another notable setback in this endeavor ( The observed discrepancy between promising preclinical and epidemiological data and the negative outcomes of a large-scale clinical trial in established Alzheimers disease (AD) necessitates a thorough analysis