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instead, they represent a collapse in proteostasis resilience, the intrinsic ability of cells to sense stress, mobilize coordinated responses and restore equilibrium across multiple proteostatic axes

They take what you eat and turn it into ATP, the fuel cells run on

Zebrafish offer several advantages: optical transparency, rapid development, and high fecundity, combined with strong conservation of immune cell types and inflammatory signaling pathways (approximately 70%82% genomic homology with humans) (Howe et al., 2013

We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs