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Preclinical studies by Lv and colleagues have shown that GLP-1s can restore dopamine levels, inhibit dopaminergic loss, attenuate neuronal degeneration, and alleviate motor and non-motor features of PD

135 Another study displayed that inhibiting mTOR pathway with rapamycin or Torin 1 enhanced autophagy and reduced NETs formation in PMA-stimulated neutrophils, while activating the mTOR pathway with insulin-suppressed autophagy and increased NETs formation in LPS-stimulated neutrophils

Pederson RA, Satkunaraja M, McIntosh CH, Scrocchi LA, Flamenz D, Schuit F, Drucker DJ, Wheeler MB

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