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Acknowledgements We would like to acknowledge significant contributions to this study from our 108 Pioneers, S

It started with GLP-1s shaping the cultural fabric, as evidenced by the changes Starbucks made to their menu

GLP-1 is a hormone secreted in the gut after eating

Compared with older pharmacologic options, GLP-1 receptor agonists and newer incretin-based therapies generally offer greater average weight reduction, but they also raise specific issues related to gastrointestinal tolerability, long-term continuation, affordability, and access ( 6 Safety and practical prescribing considerations in KOA patients Safety considerations are particularly important when GLP-1 receptor agonists are considered for patients with obesity-related KOA, because this population often includes older adults, patients with multimorbidity, and individuals approaching elective arthroplasty