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J Biol Chem 284:43645

Evidence for these links are multiple, as summarized by (253): 1) Injecting mice with LPS or inflammatory cytokines induces a depression-like behavior

AM J Case Rep 2014

The most cited concern is the same as for GH therapy: IGF-1 elevation has a complex relationship with cancer risk in epidemiological studies, with some analyses suggesting higher IGF-1 correlates with increased risk of certain cancers, while others find the opposite in older populations where IGF-1 is already low [16]