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Additionally, a relaxation process was implemented, optimizing the predicted structures further to attain more realistic and energetically favorable conformations

A comprehensive review of the FDA-approved labels of diabetes drugs: indications, safety, and emerging cardiovascular safety data

This is an emerging area of research and not yet clinically actionable, but it explains why two people on the same dose can have noticeably different responses in the first 4 to 8 weeks

However, increasing use of cardioprotective therapies (e.g., statins, SGLT2 inhibitors) and improved risk factor control over time may lower baseline event rates, potentially attenuating the absolute number of preventable events