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Despite no evidence of this same effect in humans, GLP-1s aren't recommended for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome 2 (MEN 2)

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The more clinically important question is how often this produces meaningful perioperative harm, which patients are at highest risk, and how clinicians should balance aspiration prevention against the metabolic, cardiovascular, logistical, and equity-related consequences of withholding therapy

A vial of lyophilized retatrutide stored in the freezer might remain potent for over a year