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As for women, a randomized, doubleblind, placebocontrolled clinical trial involving 150 women (aged 18-39) with clomiphene-resistant PCOS found that adding NAC (1.2 grams/day for five days starting on day three of the cycle) to clomiphene citrate significantly increased both ovulation and pregnancy rates

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As a biguanide antihyperglycemic agent, metformin works primarily by decreasing hepatic glucose production, reducing intestinal absorption of glucose, and improving insulin sensitivity in peripheral tissues

If the needle is too short for the person, or the angle is wrong, the dose can end up in subcutaneous fat, where absorption is slower and less predictable