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Dulaglutides safety profile is consistent with other GLP-1 receptor agonists, with transient nausea being the most frequently reported adverse event (14.6% incidence). Dose escalation from 0.75 to 1.5 mg is recommended after at least four weeks, based on individual glycemic control needs [57]

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Moreover, its role extends beyond glycemic control, offering additional benefits in mitigating cardiovascular risks, including the potential for stroke or heart attack

Specifically, the integration of GOx-triggered H 2 O 2 self-supply, GSH depletion-amplified Fenton-like reactions, and DOX-mediated chemotherapy collaboratively improved the tumor microenvironment, exerting a crucial role in cancer eradication