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The study additionally showed that ROSE-010 was most helpful at relieving pain in IBS-C and IBS-M ( GLP-1 agonists, such as ROSE-010, relieve pain in IBS patients by altering gut motility ( in vitro and in vivo , GLP-1 has been frequently demonstrated to reduce GI muscle activity via nerve-mediated mechanisms reliant on nitric oxide ( Constipation-predominant IBS was linked to lower mucosal expression of GLP-1R and blood GLP-1 concentrations (58)

People with obesity and an autoimmune disease and taking a GLP-1RA medication had a 17% lower risk of blood clots forming in a vein (venous thromboembolism)

Stay Hydrated : Ensure you drink plenty of water, especially when taking supplements, as hydration can affect absorption and overall wellness

Semaglutide, by contrast, activates GLP-1 receptors in the brain and pancreas to reduce appetite, slow stomach emptying, and improve blood sugar control