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2.2.3 Key regulatory networks The tumor suppressor p53 can transcriptionally repress SLC7A11 expression, diminishing cystine uptake, curtailing GSH synthesis, and thereby promoting ferroptosis ( Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating redox homeostasis

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The change of absorbance at 485 nm as a consequence of adrenochrome generation is indicative of superoxide formation ( 3.2 Hydrogen peroxide 3.2.1 Dichlorofluoresceine Frequently MitoSOX measurements are associated with staining with 5-(and -6)-carboxy-2,7-dichlorodihydrofluoresceine diacetate (DCFH-DA) for the evaluation of H 2 O 2 basal content