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& Dai, D.-Q

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The Neh2 domain, which contains ETGE and DLG motifs, is pivotal for Keap1 binding and ubiquitination, whereas the Neh1 domain features a basic leucine zipper (bZIP) structure essential for DNA binding and dimerization with small Maf proteins [17]

By diminishing Bcl-2 levels, GPS shifts the equilibrium between pro-apoptotic and anti-apoptotic proteins towards apoptosis