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Causes of IC/PBS Pelvic floor dysfunction Hormonal deficiencies Central Nervous Dysfunction Repetitive Urinary Tract Infections Orthopedic injuries/trauma Surgical trauma Endometriosis GI dysregulation Causes of IC/PBS Pelvic floor dysfunction Hormonal deficiencies Central Nervous Dysfunction Repetitive Urinary Tract Infections Orthopedic injuries/trauma Surgical trauma Endometriosis GI dysregulation Diagnostic Challenges Many experts understand IC/PBS and its various subtypes, recognizing that IC/PBS is not a disease of the bladder but rather a syndrome that can be managed with effective interdisciplinary, coordinated care