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Using the second harmonic generation properties of fibrilar collagen and multi-photon microscopy, we confirmed that fibroblasts from former smokers with COPD were unable to efficiently remodel collagen into fibrils (Figure 6d)

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In keeping with this concept, exposure of human spermatozoa to ROS generated by xanthine oxidase disrupts the functional competence of spermatozoa at levels that have little impact on somatic cells and, importantly, this effect can be reversed by the addition of catalase [21, 22]