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The PZQ plasma exposure, measured by C max , is substantially lower than the LD 50 against adult worms and NTS reported by others 61,62 , and substantially below the LD 50 for NTS killing measured herein (2743 M)

It is a first-in-class dual agonist that simultaneously activates two distinct receptor pathways: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor

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Hormonal variations can affect the viscoelastic properties of the ACL, which describes its ability to absorb and dissipate energy