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Anti-angiogenic mechanism Natural products exert their anti-angiogenic effect through the inhibition of key molecular targets such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-alpha (HIF-1), as well as direct effect on endothelial cells, such as human umbilical vein endothelial cells (HUVECs), inhibiting their proliferation and ability to form capillary-like structures

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