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doi: 10.1152/ajpregu.00414.2009

Generally, GI overproduction of reactive species with oxidative potential can be attributed to both exogenous factors (e.g., smoking, diet, alcohol, and drugs) and endogenous factors (e.g., cellular respiration, respiratory burst, xanthine oxidase, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, cyclooxygenase (COX), transition metals, nitric oxide synthase (NOS), and myeloperoxidase (MPO), which can collectively lead to pathological conditions 88

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That origin story is not incidental: much of the entire epithalon evidence base traces back to Khavinson's research group decades of work and a large body of published papers, the majority from the same investigators