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Due to these unique features, Immunocal has been used as a cysteine delivery system to boost GSH levels in individuals diagnosed with diseases for which oxidative stress is a prominent underlying factor [31, 32, 49]

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Since system X c functions as a primary source of cysteine for GSH biosynthesis, these erastin-resistant cells might have developed an alternative source to provide cysteine, compensating the shortage of cystine influx resulting from system X c blockage

However, its effectiveness can be limited by factors such as tumor type, size, location, and interpatient variability (Bazak et al