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Notably, 13 genes and their corresponding proteins were upregulated in group H-IMF, including LCN2 (Lipocalin 2), MPO (Myeloperoxidase), CATHL4 (Cathelicidin 4), ACAN (Aggrecan), TTN (Titin), CATHL3 (Cathelicidin 3), CHAD (Chondroadherin), PGLYRP1 (Peptidoglycan Recognition Protein 1), AZU1 (Azurocidin 1), COL2A1 (Collagen Type II Alpha 1 Chain), PRG3 (Proteoglycan 3), and NGP (Neutrophilic Granule Protein)

Recommended form: Vitamin D3 (cholecalciferol), paired with K2 (MK-7 form) for optimal calcium routing

[1] The shuttle is regulated at the CPT-I level, being inhibited by malonyl-CoA from beta oxidation, preventing a futile cycle

It is still under clinical research and has not yet received full regulatory approval