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In this context, several microbiota-derived metabolites, including SCFAs, trimethylamine (TMA), bile acids, coprostanol, phenylacetylglutamine, and lipopolysaccharide (LPS), have gained attention due to their established involvement in cardiovascular diseases (21)

In a phase 2 clinical trial for type 2 diabetes, people taking 12 mg of retatrutide achieved significant blood sugar reductions and lost an average of 17% of their body weight in 36 weeks (about eight months)

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