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Regular monitoring and adjustment of calorie intake throughout treatment helps maintain adequate nutrition while optimizing weight loss outcomes

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28 Oral administration does not appear to diminish the glucose-lowering or weight-lowering efficacy of semaglutide, 29 with oral semaglutide comparing favorably when studied against the SGLT-2 inhibitor empagliflozin

However, some protocols inject near the area of interest (e.g., near an injured tendon) for potentially higher local concentrations while still achieving systemic distribution