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2016;5(8):e003190

Medial preoptic area and hypothalamus Next, animal and translational studies indicate that MC4R activation in the medial preoptic area of the hypothalamus may increase dopamine release

The fusion of cisplatin with GSH, cysteine (L(+)-Cysteine), and other proteins leads to the depletion of antioxidant reserves in the cytoplasm and causes cellular oxidative stress, which is the major mode of action of cisplatin toxicity

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