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In many cases, theyre not

These encompass the utilization of chemically modified siRNAs, such as cholesterolconjugated siRNAs, the employment of viral vectors (e.g., lentiviruses) to prolong the duration of action, and the combination with lipid nanoparticles (LNPs) to improve delivery efficiency [434, 435]

As an alternative to introducing live bacteria into OoC systems, which can present technical and biosafety challenges, microbial-derived extracellular vesicles (EVs) could be used to study host responses

Using CPT1A-silenced ECs in the LPS model, Kalucka et al