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Due to their substantial surface area and good epithelial permeability and the abundant blood flow in the lungs, small particles that are deposited in the lungs are rapidly absorbed into the systemic circulation at high levels 10,11

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Although individual PRMTs may have preferences for different core histone substrates (H2A, H2B, H3, and H4), most arginine methylations imply the activation of gene expression (Figure 2 and Table 1)

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