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While they do not directly restore the lipid lamellae of the stratum corneum, they do support the structural foundation upon which barrier function depends

We typically recommend a 24 week break after 812 weeks on for chronic protocols the necessity isn't fully established, but it's a sensible conservative approach for long-term use

STAR580 and STAR635P fluorophores were excited using a 561 nm and 640 nm laser line, depleted using 775 nm laser line and the emission was detected in the 605625 nm and 650720 nm range, respectively, in the STED mode

This regulatory stance underscores the need for caution , emphasizing the importance of consulting healthcare professionals and participating in structured clinical trials to ensure safety, efficacy, and compliance with local laws