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One commenter noted that rural hospitals already contend with physician shortages, maternity care deserts, and ongoing obstetric unit closures, and cautioned that capping or reducing these hospitals' Overall Hospital Quality Star Rating could exacerbate rural health disparities, particularly in maternal health outcomes

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DOI: 10.1016/j.peptides.2005.01.029 Anti-Inflammatory Melanocortin Signalling Research using MT-2 as a pharmacological tool has investigated MC3R and MC4R-mediated anti-inflammatory pathways in macrophage, keratinocyte, and neuronal cell models, including NF-B pathway suppression, pro-inflammatory cytokine downregulation, and melanocortin-mediated immune modulation research areas of relevance to neuroinflammation and peripheral inflammatory signalling biology