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Intracellular glutathione levels decline with age, chronic inflammation, and certain genetic variations affecting glutathione synthesis or recycling

Antioxidant 9(8):681

Evidence supports several interventions: Cognitive behavioral therapy (CBT) : Randomized controlled trials demonstrate that CBT specifically designed for menopausal symptoms reduces hot flash-related distress and improves quality of life, even when frequency remains unchanged [35] [36] Clinical hypnosis : Studies show significant reductions in hot flash frequency and interference with daily activities [40] Weight management : Obesity correlates with increased hot flash severity

MRSI, Magnetic resonance spectroscopy imaging