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By the late 1970s admissions to hospital and the workload of gastric surgeons had begun to decline as a result of the introduction of H2 receptor agonists, a new class of drugs that block the action of histamine

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Dysregulation of GLP-1R signaling contributes to impaired insulin secretion, altered lipid homeostasis, hyperglycemia, and metabolic dysfunction observed in obesity and type 2 diabetes [1]