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[1] [2] Lower BMI thresholds apply for certain ethnic groups

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This inefficient transfer of energy in turn creates hydroxyl radicals which hook onto the nitrogen bases of DNA

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It binds with high affinity across multiple melanocortin receptor subtypes: MC1R (Ki approximately 0.67 nM), MC4R (approximately 6.6 nM), MC3R (approximately 34 nM), and MC5R (approximately 46 nM)

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Sun L, Xie C, Wang G, et al

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