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(2012) reported decreased CSF total tau and normal phospho tau both in PD and PDD, while total tau was increased in CBD and normal in PSP, DLBD, and MSA, and phospho tau was decreased in PSP and MSA in comparison with controls

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L-citrulline and citrulline malate supplements are generally safe for healthy individuals, and research has used doses of up to 15g/day without serious adverse effects.15 Like any supplement, even the healthiest individuals might experience some nausea, headaches, or gastrointestinal discomfort when beginning a new regimen