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In this context, the combination of estrogen therapy and GLP-1 receptor agonists represents perhaps the most metabolically direct version of the integrated approach this article has been building toward

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence

The role of dorsomedial hypothalamus (DMH) glucagon-like peptide-1 receptor (GLP-1R) neurons regulating cognitive satiation can be likened to stepping on a vehicles brake in response to traffic signals - a preemptive action taken before reaching the actual stop goal, reflecting a feed-forward control mechanism