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The compound progressed through Phase 2 trials under multiple sponsors for postoperative ileus and related gastric-motility indications, with one randomized controlled trial published in 2014, but did not advance to a marketed therapeutic in any major jurisdiction

Malpractice insurers might refuse coverage if a claim arises from an activity that is unlawful or outside the scope of standard practice

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These new vessels bring with them small nerves, which have been shown to be one of the causes of the pain in Achilles tendon problems