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Similarly, the SCALE (Satiety and Clinical AdiposityLiraglutide Evidence) trials published in The Lancet (2015) demonstrated that liraglutide 3.0 mg daily resulted in approximately 8% weight loss over 56 weeks

Key safety concerns include potential insulin sensitivity effects linked to certain CLA isomers and the possibility that L-carnitine increases TMAO via gut bacteria in some people which has been associated with cardiovascular risk in observational studies

Short-term treatment with liraglutide positively impacts the microbiome, while prolonged dulaglutide treatment leads to gradual changes in the microbial community, mirroring the slow and steady progress in glycemic control, weight loss, and reduction of inflammation [99,100]