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33 Increased telomere attrition in these T cells exacerbates the inflammatory state and is associated with the development of cardiovascular disease in RA patients, indicating the systemic effects of immunosenescence

KYNA acts as a selective ligand for the GRP35 receptor [124], and its activation on immune cells suppresses the production of pro-inflammatory cytokines

Recent studies have also reported that IF exerts a beneficial effect in different models of central nervous system (CNS) disorders or aged brain [12, 13]

Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging