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Inhibition varies between 30 and 80 % depending on the dose of UA, time of exposure, and different cell lines or different animal studied

Statistical analysis and data graphing were performed using IBM SPSS 26.0, GraphPad Prism 8.0.1, and R 4.3.2

Chung JS

The European Federation of Neurological Societies guidelines on neuropathy recommend pregabalin, gabapentin, duloxetine, tricyclic antidepressants, and venlafaxine for first-line treatment, with opioids and tramadol reserved for second-line therapy [37]