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Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

Consider reescalation to 2.4 mg once weekly

The relationship between GLP-1 receptor agonists and thyroid function is complex and not fully understood, which has prompted further investigation into the safety and efficacy of semaglutide in patients with thyroid disorders