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[2] Systemically, angiogenic activity is a double-edged property in principle helpful for perfusing regenerating tissue, but something that any candidate with pro-angiogenic signaling must be evaluated against carefully in other contexts, including any setting where promoting blood-vessel growth would be undesirable

Stokke O, Marstein S, Jellum E, Lie SO: Accumulation of pyroglutamic acid (5-oxoproline) in homocystinuria

It is extensively studied in preclinical models for its ability to promote dendritic spine formation, enhance synaptic plasticity, and support neuronal regeneration