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This was evident in the LIVE and FIGHT trials, in which liraglutide, despite leading to significant weight loss compared with placebo, failed to demonstrate any beneficial effects on clinical outcomes or left ventricular ejection fraction (LVEF) in patients with HFrEF

[Timeline and prevalence references available in full document] 100

Additionally, the absence of standardized testing methods for measuring oxidative stress in clinical settings hinders early diagnosis and the development of customized treatment plans

Abstract Insulin-like growth factor-1 (IGF-1) is a pleiotropic protein hormone and has become an attractive therapeutic target because of its multiple roles in various physiological processes, including growth, development, and metabolism