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Disrupted peripheral neurogenic signaling pathways between the liver and the brain axis, coupled with perturbed central neurotransmission within the brain, in tandem with disease-related or disease-associated factors, such as complications, treatments, and severity, as well as alcohol use, metabolic syndrome, and malignancy, collectively contribute toward clinical fatigue (10)

In healthy young rodents with intact synaptic networks, the same doses produce minimal measurable change in cognitive performance

Competitive athletes needing substance-tested supplements

Endothelial glycocalyx in traumatic brain injury associated coagulopathy: potential mechanisms and impact