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Exploration of the shared pathways and common biomarker PAN3 in ankylosing spondylitis and ulcerative colitis using integrated bioinformatics analysis

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Additionally, disruptions in the TCA cycle, a central hub of cellular respiration (62), suggest impaired mitochondrial energy production, leading to further metabolic inefficiencies

Under normal conditions, TNF- signaling facilitates the recruitment of RIPK1 kinase to the plasma membrane, forming membrane-associated complex , which includes RIPK1, TRADD, TNF receptor-associated factor (TRAF), and cellular inhibitors of apoptosis proteins (cIAP1/2) (Holler et al., 2000)