Moreover, the multifunctional sodium alginate rapidly cross-linked to form a hydrogel in the presence of physiological concentrations of Ca 2+ , which can slowly and continuously release loaded hyaluronidase, DOX, and micellar IP-NPs, thereby effectively promoting the maturation of DCs and activating T lymphocytes, ultimately generating long-term immune memory (203)
Immediate medical attention is required if thirst occurs alongside signs of severe dehydration (dizziness, confusion, reduced urine output), persistent vomiting preventing oral intake, or symptoms suggestive of diabetic ketoacidosis (persistent high blood glucose, abdominal pain, rapid breathing, altered consciousness)
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