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[1] [5] While there is limited evidence that GLP-1 receptor activation may influence sodium excretion (natriuresis) in experimental settings, this has not translated to clinically significant urinary frequency in clinical trials or post-marketing surveillance

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Adult patients with type 2 diabetes inadequately controlled on metformin (1500 mg/day) and Januvia (100 mg/day) for at least 90 days prior to screening (N=407) were randomized 1:1 to switch to once-daily Victoza 1.8 mg in addition to a Januvia placebo or continued Januvia 100 mg in addition to a Victoza placebo, both in combination with metformin

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE