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The stress management strategies that matter most for menopausal metabolic health are those that reduce cortisol output consistently rather than episodically

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In the process of hepatocellular steatosis, one of the hallmarks of MASLD is the appearance of the UPR in hepatocytes, which can inhibit mitochondrial lipid oxidation through the UPR-induced ATF-6 pathway and promote fatty acid synthesis via the PERK, ATF-6 and IRE1 signaling pathways, which together promote intracellular lipid accumulation (67,68)

With appetite suppressed, GLP-1 users need to be hyper-focused on ensuring that what they do eat and drink provides the right nutrition