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Important cautions include avoiding use in patients with severe gastroparesis or other severe gastrointestinal disease, monitoring for diabetic retinopathy complications (particularly in patients with pre-existing retinopathy), and avoiding use during pregnancy with a recommended washout period of at least 2 months before planned conception

The contrasting poorer response in MASLD, where improvement rates were lower and MELD-3 more unfavourable, is also consistent with the literature

For some, symptoms may gradually improve and disappear completely while some may need to continue with treatment indefinitely

Concentration formula: mg/ml = total mg in vial ml of water added