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Although trial results are promising, retatrutide is not yet licensed by the MHRA

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In a study comparing the effects of semaglutide and tirzepatide for weight loss, those receiving tirzepatide were more likely to achieve 5% or greater, 10% or greater, and 15% or greater weight loss and experienced larger reductions in body weight at 3, 6, and 12 months

The exact reason isnt fully understood, but the dose-dependent pattern across multiple medications suggests it may be related to how these drugs interact with nerve signaling at higher concentrations