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Hormonal Balance Perimenopause is caused by fluctuating hormone levels, leading to symptoms like mood swings, brain fog, fatigue, and irregular menstrual cycles

A staged pathway may include: Medical weight-loss treatment to reduce risk before surgery Gastric sleeve surgery for more durable weight reduction Long-term nutritional and behavioural support Medication after surgery where clinically appropriate This approach recognises obesity as a chronic condition that requires long-term care, not a short-term intervention

Both classes of medicine also promote weight loss, especially GLP-1 receptor agonists

Potential applications in age-related muscle loss (sarcopenia) or disease-related muscle wasting remain speculative pending investigation of BPC-157's effects on muscle mass maintenance and protein synthesis in chronic conditions