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Research shows that combining higher protein intake with resistance exercise preserves lean mass and improves body composition during caloric deficit, and a 2025 systematic review found that exercise interventions alongside GLP-1 medications produced better outcomes for body composition than medication alone
Exendin-4 has been shown to reduce advanced glycation end product (AGE)-induced interleukin (IL)-6 and TNF- production, the expression of receptor for AGE (RAGE), and cell death in mesangial cells (Wang et al., 2014)
A study published in the Journal of Pharmacy Technology compared oral and injectable semaglutide and found no significant differences in weight loss or blood sugar control after 26 weeks
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