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Examples of CNS depressants include: Opioids, such as OxyContin (oxycodone), Vicodin (hydrocodone), and codeine Benzodiazepines, such as Valium (diazepam), Xanax (alprazolam), and Ativan (lorazepam) Antipsychotics, such as Haldol (haloperidol), Seroquel (quetiapine), and Risperdal (risperidone) Sedative-hypnotics, such as Ambien (zolpidem), Lunesta (eszopiclone), and Sonata (zaleplon) Barbiturates, such as Luminal (Phenobarbital), Seconal (Secobarbital), and Amytal (Amobarbital) Medications that affect how tramadol is processed in the body Several drugs can alter how tramadol is processed, which may lead to increased side effects or reduced effectiveness

Individuals may experience a decline in exercise tolerance and overall muscle performance

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This situation is changing rapidly and additional impacts may arise of which we are not currently aware and may exacerbate other previously identified risks