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Elevated ROS levels in OA synovium have been confirmed experimentally, where mean fluorescence intensity of ROS is markedly higher than in healthy controls, indicative of pronounced oxidative stress in OA joints (149)

clinical data is thin

Uncarboxylated osteocalcin inhibits high glucose-induced ROS production and stimulates osteoblastic differentiation by preventing the activation of PI3K/Akt in MC3T3-E1 cells

Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure-Guided Strategy vs an Empirical High PEEP-Fio 2 strategy on death and days free from mechanical ventilation among patients with acute respiratory distress syndrome: a randomized clinical trial