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Interestingly, bioinformatic analyses conducted on bulk tissue data obtained from healthy human brain tissue donors revealed that endothelial cells and microglia were the predominant senescent cell types, driven by CDKN1A/ p21 WAF1 /CIP1 (42) revealing potential differences in senescent cell types between healthy and diseased states

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Alistipes , identified as a potential producer of short-chain fatty acids (SCFA), contribute to modulating inflammatory responses, with decreased levels linked to hepatic fibrosis (46)

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